Human CD98 PE-conjugated Antibody

FAB5920P has been discontinued. View all CD98 products.
    
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  • Species Reactivity
    Human
  • Specificity
    Detects human CD98 in direct ELISAs.
  • Source
    Monoclonal Mouse IgG2A Clone # 590559
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Chinese hamster ovary cell line CHO-derived recombinant human CD98
    Asp105-Gln529
    Accession # P08195
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of CD98 in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human CD98 PE‑conjugated Monoclonal Antibody (Catalog # FAB5920P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CD98
CD98, also known as 4F2hc, is a ubiquitously expressed, 85-95 kDa member of the SLC3 (solute carrier 3) family of amino acid transporters. It is a type II transmembrane glycoprotein that covalently-associates with a variable number of small, 38-45 kDa, 12-transmembrane proteins that belong to the SLC7 family of molecules. The 120-130 kDa heterdimeric 4F2 complex is known to transport neutral or cationic amino acids with, or without, a contribution of sodium. It also interacts with Integrin beta 1 and beta 3 to promote cell polarization and migration. Notably, CD98 is "vertebrate-restricted," and its appearance evolutionarily has been linked to the onset of tumorigenesis. Over amino acids (aa) 105-529, human and mouse CD98 share 76% aa sequence identity.
  • Entrez Gene IDs:
    6520 (Human); 17254 (Mouse)
  • Alternate Names:
    4F2; 4F2hc; 4T2HC; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC; CD98 antigen; CD98 heavy chain; CD98; CD98HC; CH98hc; FRP-1; heavy chain; Lymphocyte activation antigen 4F2 large subunit; MDU1antigen defined by monoclonal 4F2, heavy chain; monoclonal 44D7; NACAE4F2 cell-surface antigen heavy chain; SLC3A2; solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen
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