Human Chondromodulin-1 (NP_008946) VersaClone cDNA

Name: Human Chondromodulin-1 (NP_008946) VersaClone cDNA
Brand: R&D Systems
SKU: RDC1409
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC1409

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Product Documents

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Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species

Human

Accession Number

NP_008946

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Chondromodulin-1

LECT1 encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternate Names

BRICD3, ChM-1, Chondromodulin1, LECT1

Entrez Gene IDs

11061 (Human); 16840 (Mouse); 81512 (Rat)

Gene Symbol

CNMD

UniProt

NP_008946

Additional Chondromodulin-1 Products

Product Documents for Human Chondromodulin-1 (NP_008946) VersaClone cDNA

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Certificate of Analysis

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Product Specific Notices for Human Chondromodulin-1 (NP_008946) VersaClone cDNA

For research use only

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