Human CMG-2/ANTXR2 (NP_001139266) VersaClone cDNA Summary
CMG-2 is an anthrax toxin receptor (ATR) family protein that contains one von Willebrand factor type A domain. As a result of alternative splicing, at least four isoforms of secreted or type I membrane proteins exist. CMG-2 is widely expressed in human tissues. It binds selectively to collagen type IV and laminin and is also capable of binding the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner. Soluble CMG-2 is a potent antitoxin and may be used as a treatment for anthrax.
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