Human Connexin 46/GJA3 (AAD42925) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC0535
Product Details
Citations (1)
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Human Connexin 46/GJA3 (AAD42925) VersaClone cDNA Summary

Key Benefits

GJA3 (Connexin 46) is a component of lens fiber gap junctions. Congenital cataract is the leading cause of visual disability in children. Defects in GJA3 are a cause of zonular pulverulent cataract type 3. Both normal hypoxic tissue (lens) and adaptive hypoxic tissue (breast tumor) utilize GJA3 as a protective strategy from hypoxia. GJA3 may provide a new direction for drug development for breast cancer treatment.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: Connexin 46/GJA3

GJA3 (Connexin 46) is a component of lens fiber gap junctions. Congenital cataract is the leading cause of visual disability in children. Defects in GJA3 are a cause of zonular pulverulent cataract type 3. Both normal hypoxic tissue (lens) and adaptive hypoxic tissue (breast tumor) utilize GJA3 as a protective strategy from hypoxia. GJA3 may provide a new direction for drug development for breast cancer treatment.

Alternate Names
CAE3; Connexin 46; connexin-46; CX46; CX46gap junction alpha-3 protein; CZP3; gap junction protein, alpha 3, 46kD (connexin 46); gap junction protein, alpha 3, 46kDa (connexin 46); gap junction protein, alpha 3, 46kDa; GJA3

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Citation for Human Connexin 46/GJA3 (AAD42925) VersaClone cDNA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Development of a Cx46 Targeting Strategy for Cancer Stem Cells
    Authors: EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia
    Cell Rep, 2019;27(4):1062-1072.e5.  2019

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