Human CRELD2  alpha Isoform Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CRELD2

CRELD2 is an ubiquitously expressed protein that is a second member of the CRELD family of matricellular proteins. Human CRELD2 alpha isoform is synthesized as a 353 amino acid residue precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE), and EGF-like repeats. Multiple isoforms, including the beta isoform with a 27 aa substitution for the C-terminal 96 residues of the alpha isoform, and another isoform with a 32 residue deletion between residues 258 and 289, have been reported. Human CRELD2 has been shown to interact with the alpha 4 subunit of the nicotinic acetylcholine receptor and function as a specific regulator of receptor expression. Human CRELD2 shares 76% and 77% amino acid sequence homology with mouse and rat CRELD 2, respectively.

Product Datasheets