Human DAP10/HCST Alexa Fluor® 405-conjugated Antibody

FAB9786V Datasheet / COA / SDS

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FAB9786V-100UG

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Human DAP10/HCST Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human DAP10/HCST in direct ELISAs.

Source

Monoclonal Mouse IgG_2A Clone # 982129

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Synthetic peptide containing human DAP10/HCST
Accession # Q9UBK5

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

U937 Human Histiocytic Lymphoma Cell Line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: DAP10/HCST

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

Entrez Gene IDs

10870 (Human); 23900 (Mouse); 474146 (Rat)

Alternate Names

DAP10; DAP10PIK3AP; DKFZP586C1522; HCST; hematopoietic cell signal transducer; KAP10; KAP10DNAX-activation protein 10; kinase assoc pro of ~10kDa; Kinase Assoc Protein; Membrane protein DAP10; phosphoinositide-3-kinase adaptor protein; PIK3AP; Transmembrane adapter protein KAP10