Human DC-STAMP Alexa Fluor® 750-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB7824S-100UG
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Human DC-STAMP Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human DC-STAMP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse DC-STAMP is observed.
Source
Monoclonal Mouse IgG2b Clone # 788524
Immunogen
E. coli-derived recombinant human DC-STAMP
Asp314-Thr376
Accession # Q9H295
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 750

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
Human mature dendritic cells derived from CD14+ Human peripheral blood mononuclear cells (PBMCs) treated with Recombinant Human IL-4 (Catalog # 204-IL) and Recombinant Human GM-CSF (Catalog # 215-GM) for 6 days then treated with LPS, Recombinant Human TNF-alpha (Catalog # 210-TA), and Recombinant Human IL-1 beta (Catalog # 201-LB) for 24 hours

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: DC-STAMP

DC-STAMP, also known as TM7SF4, is an approximately 50 kDa glycoprotein with seven transmembrane segments. It is expressed on the surface of dendritic cells and monocytes as well as on osteoclasts and their progenitors. DC-STAMP binds CTGF/CCN2 and cooperates with TRANCE/RANK L for inducing osteoclast differentiation and fusion into multinucleated cells. It contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and associates with FC gamma RIII/CD16. Within aa 314-376, human DC-STAMP shares approximately 75% aa sequence identity with mouse and rat DC-STAMP.

Long Name
Dendritic Cell-specific Transmembrane Protein
Entrez Gene IDs
81501 (Human); 75766 (Mouse); 299889 (Rat)
Alternate Names
DCSTAMP; DC-STAMP; dendritic cell-specific transmembrane protein; FIND; IL-4-induced Protein; TM7SF4; transmembrane 7 superfamily member 4

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