Human EDA2R/TNFRSF27/XEDAR Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # AF1093AFP488

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Blockade of Receptor-ligand Interaction

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Polyclonal Goat IgG
View all EDA2R/TNFRSF27/XEDAR Primary Antibodies »

Product Specifications

Specificity

Detects human EDA2R/TNFRSF27/XEDAR in direct ELISAs and Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human EDA2R/TNFRSF27/XEDAR Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Blockade of Receptor-ligand Interaction

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: EDA2R/TNFRSF27/XEDAR

X-linked ectodysplasin receptor (XEDAR) is a type III transmembrane that lacks an N-terminal signal peptide. It is an X-linked member of the TNF Receptor Superfamily (TNFRSF). Human XEDAR is a 297 amino acid (aa) protein with a 136 aa extracellular domain, a 21 aa transmembrane domain, and a 140 aa cytoplasmic domain. Within the TNFRSF, XEDAR shares the highest homologies with EDAR and TNFRSF19/TROY. EDA-A2 is the XEDAR ligand. XEDAR expression is principally found in embryonic hair follicles. XEDAR, EDAR, EDA-A1 and EDA-A2 have been associated with hypohidrotic ectodermal dysplasia (HED). HED is characterized by abnormalities in hair, teeth, and eccrine sweat gland morphogenesis. HED was initially found to associate with two gene loci, tabby and downless. Tabby was later identified as the gene for EDA and downless as the autosomal EDAR gene. EDA has two splice variants, EDA-A1 and EDA-A2 which differ by only two amino acids. Despite this minor difference, the EDA isoforms display strong receptor specificity. EDA-A1 only binds EDAR, whereas EDA-A2 only binds to XEDAR. Mutations in EDA, EDAR and XEDAR have been associated with HED.

References

  1. Headon, D.J. and P.A Overbeek (1999) Nat. Genet. 22:370.
  2. Kumar, A. et al. (2000) J. Biol. Chem. 276:2668.
  3. Monreal, A.W. et al. (1999) Nat. Genet. 22:366.
  4. Schneider, P. et al. (2001) J. Biol. Chem. 276:18819.
  5. Srivastava, A.K. et al. (1997) Proc. Natl. Acad. Sci. USA 94:13069.
  6. Yan, M. et al. (2000) Science 290:523.

Long Name

Ectodysplasin A2 Receptor

Alternate Names

EDAA2R, TNFRSF27, XEDAR

Entrez Gene IDs

60401 (Human); 245527 (Mouse); 710244 (Rhesus Macaque)

Gene Symbol

EDA2R

UniProt

Q9HAV5

Additional EDA2R/TNFRSF27/XEDAR Products

Product Documents for Human EDA2R/TNFRSF27/XEDAR Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human EDA2R/TNFRSF27/XEDAR Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

NFkB Pathway
p53 Pathway

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