Human ENPP-3/CD203c APC-conjugated Antibody

FAB5756A has been discontinued. View all ENPP-3/CD203c products.
  
  • Species Reactivity
    Human
  • Specificity
    Detects human ENPP‑3/CD203c.
  • Source
    Monoclonal Mouse IgG1 Clone # NP4D6
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    HEK293 human embryonic kidney cell line transfected with human ENPP‑3/CD203c
    Accession # O14638
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Allophycocyanin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of ENPP‑3/CD203c in Human Whole Blood Lymphocytes and Monocytes by Flow Cytometry. Human whole blood lymphocytes and monocytes were stained with Mouse Anti-Human IL‑3 R alpha /CD123 PE‑conjugated Monoclonal Antibody (Catalog # FAB301P) and either (A) Mouse Anti-Human
ENPP‑3/CD203c APC‑conjugated Monoclonal Antibody (Catalog # FAB5756A) or (B) Mouse IgG1 Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: ENPP-3/CD203c
CD203c is a 120-130 kDa type II transmembrane glycoprotein that belongs to the ectonucleotidase family, AP superfamily of enzymes. CD203c is also known as ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP-3) and it modulates purinergic signaling by hydrolysis of nucleotide di- and tri-phosphates plus sphingosylphosphorylenosine. Although CD203c is considered to be a marker for activated basophils and mast cells, it is also found constitutively or inducibly on bile duct epithelium, hepatocytes, duodenal columnar epithelium, osteoblasts, plasmacytoid dendritic cells, airway pseudostratified ciliated columnar epithelium and renal proximal tubule S3 segment cells. Within the ECD, human CD203c shares 81% aa sequence identity with mouse and rat CD203.
  • Long Name:
    Ectonucleotide Pyrophosphatase/Phosphodiesterase 3
  • Entrez Gene IDs:
    5169 (Human)
  • Alternate Names:
    B10; CD203c antigen; CD203c; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); ectonucleotide pyrophosphatase/phosphodiesterase 3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; ENPP3; ENPP-3; gp130RB13-6; NPP3; PD-IBETA; PDNP3; PDNP3B10; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; phosphodiesterase-I beta
Related Research Areas

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