Human FPR1 Fluorescein-conjugated Antibody

Catalog #: FAB3744F
2 Citations Datasheet / COA / SDS

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FAB3744F

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Detection of FPR1 in Human Blood Monocytes by Flow Cytometry.

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Citations (2)

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Human FPR1 Fluorescein-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human FPR1. Stains human FPR1-transfected cells but not irrelevant transfectants.

Source

Monoclonal Mouse IgG_2A Clone # 350418

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

HEK293 human embryonic kidney cell line transfected with human FPR1
Met1-Lys350
Accession # NP_002020

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Fluorescein (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of FPR1 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human FPR1 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB3744F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: FPR1

FPR1, FPRL1, and FPRL2 constitute a group of 7-transmembrane segment chemotactic receptors that are expressed on phagocytes. FPR1 binding of bacterial N‑formyl‑methionyl peptides draws neutrophils to sites of infection and promotes degranulation. Human and mouse FPR1 share 73% amino acid sequence identity.

Long Name

Formyl Peptide Receptor 1

Entrez Gene IDs

2357 (Human); 14293 (Mouse); 292409 (Rat)

Alternate Names

fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor

Product Datasheets

Product Datasheet

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Citations for Human FPR1 Fluorescein-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment
Authors: L Vecchi, STS Mota, MAP Zóia, IC Martins, JB de Souza, TG Santos, AO Beserra, VP de Andrade, LR Goulart, TG Araújo
Cells, 2022;11(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Annexin A1 promotes the nuclear localization of the epidermal growth factor receptor in castration-resistant prostate cancer
Authors: STS Mota, L Vecchi, DA Alves, AO Cordeiro, GS Guimarães, E Campos-Fer, YCP Maia, BC Dornelas, SM Bezerra, VP de Andrade, LR Goulart, TG Araújo
Int. J. Biochem. Cell Biol., 2020;127(0):105838.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry