GDF-11 (Growth Differentiation Factor 11), also known as BMP-11, is closely related to GDF-8. It is widely expressed during development and plays a role in palate, vertebrae, tail, kidney, and olfactory neuron formation. GDF-11 signals through Activin type II receptors and induces phosphorylation of Smad2 to mediate axial patterning. Systemic GDF-11 levels decline with age, and administration of GDF-11 can reverse age-related cardiac hypertrophy, restore genomic integrity and muscle stem cell health, and enhance angiogenesis and neurogenesis.
Human GDF-11/BMP-11 (NP_005802.1) VersaClone cDNA
R&D Systems | Catalog # RDC3546
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: GDF-11/BMP-11
Long Name
Growth Differentiation Factor 11
Alternate Names
BMP-11, BMP11, GDF11
Entrez Gene IDs
10220 (Human)
Gene Symbol
GDF11
UniProt
Additional GDF-11/BMP-11 Products
Product Documents for Human GDF-11/BMP-11 (NP_005802.1) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human GDF-11/BMP-11 (NP_005802.1) VersaClone cDNA
For research use only
Related Research Areas
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