Human GP1BB (NP_000398) VersaClone cDNA

R&D Systems | Catalog # RDC1820

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Key Product Details

Species

Human

Accession Number

NP_000398

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: GP1BB

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alphachain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor(VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, andGPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling throughphosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated withBernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIbbeta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arisingfrom a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this producthas been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissuessuch as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signalwithin a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its ownimperfect site, the septin 5 gene uses the consensus polyA signal of this gene. (provided by RefSeq)

Long Name

Glycoprotein lb [Platelet] beta

Alternate Names

BDPLT1, CD42c, GPIb-Beta, GPIbb

Entrez Gene IDs

2812 (Human); 14724 (Mouse); 116727 (Rat)

Gene Symbol

GP1BB

UniProt

NP_000398

Additional GP1BB Products

Product Documents for Human GP1BB (NP_000398) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human GP1BB (NP_000398) VersaClone cDNA

For research use only

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