GPR18, the most abundantly overexpressed orphan GPCR in all melanoma metastases, is constitutively active and inhibits apoptosis, indicating an important role for GPR18 in tumor cell survival. GPR18 is expressed significantly in lymphoid cell lines, but not in non-lymphoid hematopoietic cell lines. N-arachidonylglycine (NAGly) induces an increase in intracellular Ca(2+) concentration in GPR18-transfected cells. GPR18 may be considered a potential novel anticancer target in metastatic melanoma.
Human GPR18 (NP_005283) VersaClone cDNA
R&D Systems | Catalog # RDC0305
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: GPR18
Long Name
G Protein-coupled Receptor 18
Alternate Names
GPCRW, NAGly Receptor
Gene Symbol
GPR18
UniProt
Additional GPR18 Products
Product Documents for Human GPR18 (NP_005283) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human GPR18 (NP_005283) VersaClone cDNA
For research use only
Related Research Areas
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