Adhesion G protein-coupled receptor G3 (ADGRG3, GPR97 or PGR26) is an orphan GPCR receptor that in vitro regulates migration of lymphatic endothelial cells via the small GTPases RhoA and CDC42. GPR97 is a 549 aminoacids (aa) 7-transmembrane domain (7TM) receptor belonging to the secretin sub-family of GPCR. Human GPR97 is expressed in granulocytes and endothelial cells of the vasculature.