Human HAPLN4 (NP_075378) VersaClone cDNA

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Human HAPLN4 (NP_075378) VersaClone cDNA
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Human HAPLN4 (NP_075378) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: HAPLN4

Hyaluronan and Proteoglycan Link Protein 4, (HAPLN4), also known as brain link protein 2, is one of four secreted HAPLN family proteoglycans that bind hyaluronan. HAPLN4 contains one Ig-type C2-set domain and two link domains. Predominantly expressed in brain, HAPLN4 participates in the development of the perineuronal matrix. Human and mouse HAPLN4 share 91% aa sequence identity.

Hyaluronan binding proteins are of two types; those with link modules, and those without. Link modules are 100 amino acid (aa) HA and protein-binding sequences that contain two alpha-helices and two anti-parallel beta-sheets. There are three categories of link module-containing proteins. A domain-type proteins contain one link module; B domain-type proteins contain one link module with an N- and C-terminal flanking region; and C domain-type proteins have an extended structure with one N-terminal V-type Ig-like domain followed by two link modules.

Long Name
Hyaluronan and Proteoglycan Link Protein 4
Entrez Gene IDs
404037 (Human); 330790 (Mouse)
Alternate Names
BRAL2; BRAL2KIAA1926Brain link protein 2; HAPLN4; hyaluronan and proteoglycan link protein 4; Lpr4


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