Human HAPLN4 (NP_075378) VersaClone cDNA Summary
Hyaluronan and Proteoglycan Link Protein 4, (HAPLN4), also known as brain link protein 2, is one of four secreted HAPLN family proteoglycans that bind hyaluronan. HAPLN4 contains one Ig-type C2-set domain and two link domains. Predominantly expressed in brain, HAPLN4 participates in the development of the perineuronal matrix. Human and mouse HAPLN4 share 91% aa sequence identity.
Hyaluronan binding proteins are of two types; those with link modules, and those without. Link modules are 100 amino acid (aa) HA and protein-binding sequences that contain two alpha-helices and two anti-parallel beta-sheets. There are three categories of link module-containing proteins. A domain-type proteins contain one link module; B domain-type proteins contain one link module with an N- and C-terminal flanking region; and C domain-type proteins have an extended structure with one N-terminal V-type Ig-like domain followed by two link modules.
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