First discovered in E.coli, HTRA null mutants had two phenotypes. They either did not grow at elevated temperatures (HTRA for High Temperature Requirement) or failed to digest misfolded proteins in the periplasm (DegP). Subsequently, prokaryotic HTRA has been attributed to the tolerance against various folding stresses and to pathogenicity. Human homologs (HTRA1 to 4) are believed to play a role in arthritis, cell growth, unfolded stress response, apoptosis, aging and tumor progression.
Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA
R&D Systems | Catalog # RDC3408
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: HTRA1/PRSS11
Long Name
High Temperature Requirement Protein-1
Alternate Names
IGFBP5-protease, PRSS11
Entrez Gene IDs
5654 (Human)
Gene Symbol
HTRA1
UniProt
Additional HTRA1/PRSS11 Products
Product Documents for Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA
For research use only
Related Research Areas
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