Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA

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Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA
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Human HTRA1/PRSS11 (NP_002766.1) VersaClone cDNA Summary


Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: HTRA1/PRSS11

First discovered in E.coli, HTRA null mutants had two phenotypes. They either did not grow at elevated temperatures (HTRA for High Temperature Requirement) or failed to digest misfolded proteins in the periplasm (DegP). Subsequently, prokaryotic HTRA has been attributed to the tolerance against various folding stresses and to pathogenicity. Human homologs (HTRA1 to 4) are believed to play a role in arthritis, cell growth, unfolded stress response, apoptosis, aging and tumor progression.

Long Name
High Temperature Requirement Protein-1
Entrez Gene IDs
5654 (Human)
Alternate Names
ARMD7; EC 3.4.21; EC; High-temperature requirement A serine peptidase 1; HtrA serine peptidase 1; HTRA1; IGFBP5-protease; L56; ORF480; PRSS11; Serine protease 11; serine, 11 (IGF binding)


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