Human IGSF2/CD101 (NP_004249) VersaClone cDNA

R&D Systems | Catalog # RDC1315

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Key Product Details

Species

Human

Accession Number

NP_004249

Background: IGSF2/CD101

CD101 is a disulfide-linked homodimeric type 1 glycoprotein. The peptide is comprised of 7 extracellular V-type IgSF domains. CD101 is highly expressed on monocytes, granulocytes, mucosal T cells, and on activated peripheral blood T cells. Expression is weak on resting T and B and NK cells, absent from platelets and weak or absent from most hematopoietic cell lines. CD101 is thought to play a co-stimulatory role in TCR/CD3-mediated T cell activation. Monoclonal antibodies against CD101 inhibit allogeneic T cell responses. Studies suggest that CD101 plays a major role in the activation of T cells by skin dendritic cells.

Long Name

Immunoglobulin Superfamily, Member 2

Alternate Names

CD101, Leukocyte Surface Protein, V7

Entrez Gene IDs

9398 (Human); 630146 (Mouse)

Gene Symbol

CD101

UniProt

NP_004249

Additional IGSF2/CD101 Products

Product Documents for Human IGSF2/CD101 (NP_004249) VersaClone cDNA

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Product Specific Notices for Human IGSF2/CD101 (NP_004249) VersaClone cDNA

For research use only

Related Research Areas

Group 1 ILCs
Regulatory T Cells (Tregs)

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