Human IL-17/IL-17A Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IL-17/IL-17A

Human IL-17A/F is an approximately 40 kDa, secreted, disulfide-linked heterodimeric glycoprotein comprised of two members of the IL-17 family of cytokines, IL-17A and IL-17F (1, 2). Members of this family demonstrate a structural motif termed a cysteine knot that also characterizes a large superfamily of growth factors. Although most cysteine knot superfamily members use three intrachain disulfide bonds to create a knot, IL-17 family molecules generate the same structural form with only two disulfide links (3-5). Mature human IL-17A and IL-17F share 61% and 56% amino acid sequence identity with mouse IL-17A and IL-17F, respectively. They share 50% aa sequence identity with each other. IL-17A/F and the IL-17A and IL-17F homodimers are produced by IL-23 activated Th17 cells (1, 6-10). The widely expressed receptors IL-17 RA and IL-17 RC form a heterodimer for the binding of IL-17A and IL-17F, as well as the heterodimeric IL-17A/F (6, 11, 12). IL-17A/F is a biologically active protein that induces chemokine production and airway neutrophilia with intermediate potency between IL-17A (most potent) and IL-17F (least potent) (7, 12). It is up-regulated in immune cells during inflammatory arthritis and contributes to disease severity (13).

Product Datasheets

Related Research Areas

• B Cell Chemotaxis, Migration, and Adhesion
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• gamma delta T Cells
• Helper T (Th) Cells
• IL-17 Family
• LTi Cells
• Macrophage Activation Markers
• Microglia Activation Markers
• Molecules Secreted by VSMC
• Multiple Sclerosis and Myelin Related Molecules
• Natural Killer T (NKT) Cells
• NCR-ILC3
• Neuroinflammatory Factors
• Search Cytokine and Growth Factor Products
• T Cell Cytokine Signaling
• Th17 Cells