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Human IL-17 Luminex Performance Assay

Catalog #: LUH317 Datasheet / COA / SDS

Discontinued Product

LUH317 has been discontinued and is replaced by LUHM317.

R&D Systems Luminex High Performance Panel
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Human IL-17 Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IL-17/IL-17A

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Long Name
Interleukin 17
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

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Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IL-17 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis.
    Authors: Chalermwatanachai T, Zhang N, Holtappels G, Bachert C
    PLoS ONE, 2015-08-14;10(8):e0136068.
    Species: Human
    Sample Types: Tissue Homogenates
  2. Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue.
    Authors: Beck I, Van Crombruggen K, Holtappels G, Daubeuf F, Frossard N, Bachert C, De Bosscher K
    PLoS ONE, 2015-04-13;10(4):e0123068.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Sputum IgE and cytokines in asthma: relationship with sputum cellular profile.
    Authors: Manise M, Holtappels G, Van Crombruggen K, Schleich F, Bachert C, Louis R
    PLoS ONE, 2013-03-26;8(0):U111.
    Species: Human
    Sample Types: Sputum
  4. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  5. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans.
    Authors: Di Meglio P, Di Cesare A, Laggner U
    PLoS ONE, 2011-02-22;6(2):e17160.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.
    Authors: Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A
    Blood, 2011-01-14;117(10):2910-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
    Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
    Eur. J. Immunol., 2010-09-01;40(9):2450-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
    Authors: Hergenroeder GW, Moore AN, McCoy JP
    J Neuroinflammation, 2010-03-11;7(0):19.
    Species: Human
    Sample Types: Serum
  10. Clinical efficacy and immune regulation with peanut oral immunotherapy.
    Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
    J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis.
    Authors: Dufresne V, Knoop C, Van Muylem A, Malfroot A, Lamotte M, Opdekamp C, Deboeck G, Cassart M, Stallenberg B, Casimir G, Duchateau J, Estenne M
    Am. J. Respir. Crit. Care Med., 2009-04-02;180(2):153-8.
    Species: Human
    Sample Types: Serum
  12. Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.
    Authors: El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, Clouet-Delannoy M, Lombardelli L, Jabrane-Ferrat N, Rukavina D, Bensussan A, Piccinni MP, Le Bouteiller P, Tabiasco J
    J. Immunol., 2008-09-01;181(0):3009-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55.
    Authors: Ullenhag GJ, Spendlove I, Watson NF, Indar AA, Dube M, Robins RA, Maxwell-Armstrong C, Scholefield JH, Durrant LG
    Clin. Cancer Res., 2006-11-22;12(24):7389-96.
    Species: Human
    Sample Types: Cell Culture Supernates

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