Human IL‑17/IL‑17A (Research Grade Secukinumab Biosimilar) Alexa Fluor™ Plus 555‑conjugated Antibody

Name: Human IL‑17/IL‑17A (Research Grade Secukinumab Biosimilar) Alexa Fluor™ Plus 555‑conjugated Antibody
Brand: R&D Systems
SKU: FAB9492AFP555
Price: 589 USD
Availability: InStock

R&D Systems | Catalog # FAB9492AFP555

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)

Antibody Source

Recombinant Monoclonal Human IgG₁ Clone # Hu71

View all IL-17/IL-17A Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Human

Isotype

IgG₁

Applications

Application

Recommended Usage

ELISA

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IL-17/IL-17A

Secukinumab is a humanized monoclonal IgG1/k antibody against proinflammatory cytokine IL-17A, and is approved for the treatment of plaque psoriasis, as well as enthesitis-related arthritis, and ankylosing spondylitis. Secukinumab binds to IL-17A with high specificity preventing the interaction with the IL-17 receptor and subsequent activation of the pathway leading to inflammation seen in these disease states. Data has shown that in the presence of secukinumab results in enhanced levels of free unbound IL-17A in the serum indicating inhibition of binding to IL-17A receptor resulting in reduced inflammation.

Long Name

Interleukin 17

Alternate Names

CTLA-8, CTLA8, IL-17A, IL17, IL17A

Entrez Gene IDs

3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)

Gene Symbol

IL17A

Additional IL-17/IL-17A Products

Product Documents

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Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only