Human INSRR Alexa Fluor® 594-conjugated Antibody
Human INSRR Alexa Fluor® 594-conjugated Antibody Summary
Accession # P14616
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
INSRR is a 175 kDa orphan receptor belonging to the insulin receptor subfamily of the receptor tyrosine kinase family. It is expressed in neuroblastoma and many adult tissues, including kidney, heart, pancreas, liver and skeletal muscle. INSRR is synthesized as a single chain type I transmembrane glycoprotein precursor and undergoes proteolytic processing to generate the mature disulfide linked alpha 2/ beta 2 tetrameric receptor. The alpha subunit is localized extracellularly while the transmembrane beta subunit contains an extracellular domain, a transmembrane segment and a cytoplasmic kinase domain. The extracellular domain of human INSRR shares approximately 90% amino acid sequence identity with mouse INSRR.
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