Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA

Name: Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA
Brand: R&D Systems
SKU: RDC0854
Price: 1079 USD
Availability: InStock

R&D Systems | Catalog # RDC0854

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_001008701

Background: Latrophilin 1/LPHN1

Latrophilin-1 is a brain-specific Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splicing sites. CIRL is endogenously cleaved into two pieces at the GPCR proteolytic site (GPS) located adjacent to the first transmembrane helix as a mechanism to compartmentalize the cell adhesion and GPCR activation functions. Latrophilin-1 has been reported to be expressed predominantly in the brain. Very weak expression has also been documented in human heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. ESTs have been isolated from brain, eye, kidney, lung, and lymph node libraries. In addition, ESTs have been isolated from the following cancer libraries: brain, choriocarcinoma, epithelioid carcinoma, kidney, and lung.

Alternate Names

CIRL1, LEC2, Lectomedin-2, LPHN1

Entrez Gene IDs

22859 (Human); 330814 (Mouse); 65096 (Rat)

Gene Symbol

ADGRL1

UniProt

NP_001008701

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Product Specific Notices for Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

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