Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA

R&D Systems | Catalog # RDC0854

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Key Product Details

Species

Human

Accession Number

NP_001008701

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Latrophilin 1/LPHN1

Latrophilin-1 is a brain-specific Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splicing sites. CIRL is endogenously cleaved into two pieces at the GPCR proteolytic site (GPS) located adjacent to the first transmembrane helix as a mechanism to compartmentalize the cell adhesion and GPCR activation functions. Latrophilin-1 has been reported to be expressed predominantly in the brain. Very weak expression has also been documented in human heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. ESTs have been isolated from brain, eye, kidney, lung, and lymph node libraries. In addition, ESTs have been isolated from the following cancer libraries: brain, choriocarcinoma, epithelioid carcinoma, kidney, and lung.

Alternate Names

CIRL1, LEC2, Lectomedin-2, LPHN1

Entrez Gene IDs

22859 (Human); 330814 (Mouse); 65096 (Rat)

Gene Symbol

ADGRL1

UniProt

NP_001008701

Additional Latrophilin 1/LPHN1 Products

Product Documents for Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human Latrophilin 1/LPHN1 (NP_001008701) VersaClone cDNA

For research use only

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