Human LRH-1/NR5A2 Antibody

R&D Systems | Catalog # PP-H2325-10

R&D Systems
Discontinued Product
PP-H2325-10 has been discontinued. An alternative/replacement product is available: PP-H2325-00. View all LRH-1/NR5A2 products.

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

Western Blot, Immunoprecipitation

Cited:

Immunohistochemistry, Western Blot, Immunoprecipitation, Chromatin Immunoprecipitation (ChIP)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG3 Clone # H2325
View all LRH-1/NR5A2 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgG3

Applications for Human LRH-1/NR5A2 Antibody

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: LRH-1/NR5A2

Liver receptor homolog-1 (LRH-1, FTF, CPF, hB1F, FTZ-F1b; NR5A2) is a member of the orphan nuclear receptor family. LRH-1 is a mammalian homolog of the Drosophila fushi tarazu Factor 1 gene product. LRH-1 is thought to be critical for development because LRH-1 knockout mice are not viable. LRH-1 is expressed in the liver, intestine, pancrease, ovary and preadipocytes.

LRH-1 is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis. A role for LRH-1 in steroidogenesis is supported by its expression in ovarian granulosa cells and corpus luteum. LRH-1 has been shown to regulate transcription of several steroidogenic genes and is known to modulate the expression of aromatase in breast adipose tissue.

Long Name

Liver Receptor Homolog 1/Nuclear Receptor Subfamily 5, Group A, Member 2

Alternate Names

B1F2, FTZ-F1 beta, LRH1, NR5A2

Entrez Gene IDs

2494 (Human)

Gene Symbol

NR5A2

Additional LRH-1/NR5A2 Products

Product Documents for Human LRH-1/NR5A2 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human LRH-1/NR5A2 Antibody

For research use only

Citations for Human LRH-1/NR5A2 Antibody

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