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Human LRH-1/NR5A2 Antibody

Catalog #: PP-H2325-10
9 Citations Datasheet / COA / SDS
Newer Version Available: PP-H2325-00
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Discontinued Product

PP-H2325-10 has been discontinued and is replaced by PP-H2325-00.

Product Details
Citations (9)
FAQs
Reviews
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human LRH-1/NR5A2 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG3 Clone # H2325
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: LRH-1/NR5A2

Liver receptor homolog-1 (LRH-1, FTF, CPF, hB1F, FTZ-F1b; NR5A2) is a member of the orphan nuclear receptor family. LRH-1 is a mammalian homolog of the Drosophila fushi tarazu Factor 1 gene product. LRH-1 is thought to be critical for development because LRH-1 knockout mice are not viable. LRH-1 is expressed in the liver, intestine, pancrease, ovary and preadipocytes.

LRH-1 is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis. A role for LRH-1 in steroidogenesis is supported by its expression in ovarian granulosa cells and corpus luteum. LRH-1 has been shown to regulate transcription of several steroidogenic genes and is known to modulate the expression of aromatase in breast adipose tissue.

Long Name
Liver Receptor Homolog 1/Nuclear Receptor Subfamily 5, Group A, Member 2
Entrez Gene IDs
2494 (Human)
Alternate Names
Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus; B1F; B1F2; fetoprotein-alpha 1 (AFP) transcription factor; FTFLRH1; FTZ-F1 beta; FTZ-F1; FTZ-F1beta; HB1F; hB1F-2; hB1FCYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; liver receptor homolog-1; LRH1; LRH-1; LRH-1CPF; NR5A2; nuclear receptor NR5A2; nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2

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Citations for Human LRH-1/NR5A2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of beta-cell failure
    Authors: J Son, W Du, M Esposito, K Shariati, H Ding, Y Kang, D Accili
    Nature Communications, 2023-02-02;14(1):558.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Reprogramming competence of OCT factors is determined by transactivation domains
    Authors: KP Kim, Y Wu, J Yoon, K Adachi, G Wu, S Velychko, CM MacCarthy, B Shin, A Röpke, MJ Arauzo-Bra, M Stehling, DW Han, Y Gao, J Kim, S Gao, HR Schöler
    Science Advances, 2020-09-02;6(36):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Steroidogenic control of liver metabolism through a nuclear receptor-network
    Authors: A Milona, V Massafra, H Vos, J Naik, N Artigas, HAB Paterson, ITGW Bijsmans, ECL Willemsen, JM Ramos Pitt, I Miguel-Ali, P Bosma, BMT Burgering, C Williamson, S Vernia, WS Dhillo, SWC van Mil, BM Owen
    Mol Metab, 2019-09-30;30(0):221-229.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ChIP
  4. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
    Authors: JR Bayrer, H Wang, R Nattiv, M Suzawa, HS Escusa, RJ Fletterick, OD Klein, DD Moore, HA Ingraham
    Nat Commun, 2018-10-10;9(1):4055.
    Species: Human
    Sample Types: Organoids
    Applications: Western Blot
  5. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis
    Authors: A Zou, N Magee, F Deng, S Lehn, C Zhong, Y Zhang
    J. Biol. Chem., 2018-04-17;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  6. LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity
    Authors: DA Miranda, WC Krause, A Cazenave-G, M Suzawa, H Escusa, JC Foo, DS Shihadih, A Stahl, M Fitch, E Nyangau, M Hellerstei, MR Wenk, DL Silver, HA Ingraham
    JCI Insight, 2018-03-08;3(5):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  7. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
    Authors: Bayrer J, Mukkamala S, Sablin E, Webb P, Fletterick R
    Proc Natl Acad Sci U S A, 2015-02-09;112(8):2467-72.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
    Authors: Holmstrom SR, Deering T, Swift GH
    Genes Dev., 2011-08-15;25(16):1674-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ChIP
  9. A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.
    Authors: Guo G, Smith A
    Development, 2010-10-01;137(19):3185-92.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot

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