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The LRRTM (leucine-rich repeat transmembrane neuronal) family consists of four type I transmembrane glycoproteins within the LRR protein superfamily. All members of this family are type I transmembrane proteins that contain 10 external LRR repeats plus a short cytoplasmic tail that binds PDF motifs. LRRTMs in mouse show distinct expression patterns during formation of the central nervous system and expression persists in adult brain. LRRTM1 polymorphisms are associated paternally with handedness and schizophrenia, while LRRTM3 may be mutated in late-onset Alzheimer’s disease.
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