Human MAN2B1 (NP_000519) VersaClone cDNA

R&D Systems | Catalog # RDC1738

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Key Product Details

Species

Human

Accession Number

NP_000519

Background: MAN2B1

MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. [provided by RefSeq]

Long Name

Mannosidase alpha, Class 2B, Member 1

Alternate Names

LAMAN, MANB, Mannosidase Alpha-B

Entrez Gene IDs

4125 (Human); 17159 (Mouse); 361378 (Rat)

Gene Symbol

MAN2B1

UniProt

NP_000519

Additional MAN2B1 Products

Product Documents for Human MAN2B1 (NP_000519) VersaClone cDNA

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Product Specific Notices for Human MAN2B1 (NP_000519) VersaClone cDNA

For research use only

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