Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate Summary
MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.
Citations for Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
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Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer
Authors: AM Cathcart, GH Bird, TE Wales, HD Herce, EP Harvey, ZJ Hauseman, CE Newman, U Adhikary, MS Prew, T Oo, S Lee, JR Engen, LD Walensky
Nat. Chem. Biol., 2020;0(0):. 2020
Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
Science Advances, 2020;6(37):. 2020
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1
Authors: Z Cao, J Xue, Y Cheng, J Wang, Y Liu, H Li, W Jiang, G Li, Y Gui, X Zhang
Oncogene, 2019;0(0):. 2019
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