MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.
Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
R&D Systems | Catalog # K-200B
Discontinued Product
K-200B has been discontinued.
View all MDM2/HDM2 products.
Key Product Details
Species
Human
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Formulation, Preparation, and Storage
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: MDM2/HDM2
Long Name
Double Minute 2 Protein
Alternate Names
HDM2
Gene Symbol
MDM2
Additional MDM2/HDM2 Products
Product Documents for Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
Product Specific Notices for Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
For research use only
Related Research Areas
Citations for Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate
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Associated Pathways
Ubiquitination Cascade Pathway
