392 results for "MDM2/HDM2" in Products
MDM2/HDM2 Products
MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 kappa Monoclonal Clone #SMP14 |
| Applications: | IHC, WB, IP |
![Western Blot: MDM2/HDM2 Antibody (SMP14)BSA Free [NB100-2736]](https://resources.rndsystems.com/images/products/MDM2-HDM2-Antibody-SMP14-Western-Blot-NB100-2736-img0001.jpg "Western Blot: MDM2/HDM2 Antibody (SMP14)BSA Free [NB100-2736]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, IP, ChIP |
![Western Blot: MDM2/HDM2 Antibody [NBP2-17247]](https://resources.rndsystems.com/images/products/MDM2-HDM2-Antibody-Western-Blot-NBP2-17247-img0027.jpg "Western Blot: MDM2/HDM2 Antibody [NBP2-17247]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 kappa Monoclonal Clone #SMP14 |
| Applications: | IHC, WB, IP |
![Western Blot: MDM2/HDM2 Antibody (SMP14)Azide and BSA Free [NBP2-80845]](https://resources.rndsystems.com/images/products/MDM2-HDM2-Antibody-SMP14-Azide-and-BSA-Free-Western-Blot-NBP2-80845-img0001.jpg "Western Blot: MDM2/HDM2 Antibody (SMP14)Azide and BSA Free [NBP2-80845]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #197702 |
| Applications: | IP |
| Reactivity: | Human |
| Assay Range: | 312-20000 pg/mL |
| Applications: | ELISA |
MDM2 antagonist; inhibits MDM2-p53 interaction
| Chemical Name: | (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #1A7 |
| Applications: | IHC, WB, ELISA, Func, Mycoplasma |
![Western Blot: MDM2/HDM2 Antibody (1A7) [H00004193-M01]](https://resources.rndsystems.com/images/products/MDM2-HDM2-Antibody-1A7-Western-Blot-H00004193-M01-img0018.jpg "Western Blot: MDM2/HDM2 Antibody (1A7) [H00004193-M01]")
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
| Chemical Name: | 4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |
| Purity: | ≥97% |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #A10E11-R |
| Applications: | IHC, WB, ICC/IF |
Hdm2 inhibitor; activates p53-dependent transcription
| Chemical Name: | 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride |
| Purity: | ≥98% |
MDM2-p53 interaction inhibitor
| Alternate Names: | NSC 652287 |
| Chemical Name: | 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol |
| Purity: | ≥97% |
High affinity MDM2 inhibitor
| Chemical Name: | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Purity: | ≥98% |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
| Chemical Name: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid |
| Purity: | ≥98% |
| Reactivity: | Human |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: MDM2/HDM2 [p Ser166] AntibodyBSA Free [NBP3-05384]](https://resources.rndsystems.com/images/products/MDM2-HDM2-[p-Ser166]-Antibody-Western-Blot-NBP3-05384-img0002.jpg "Western Blot: MDM2/HDM2 [p Ser166] AntibodyBSA Free [NBP3-05384]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, IP |
