Human MIG2 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: MIG2

MIG2 (mitogen-inducible gene-2), also known as FERMT2 or Kindlin-2, is an  approximately 80 kDa, 680 amino acid (aa), ubiquitously expressed member of the Fermitin/Kindlin family of cytoplasmic adaptor proteins. MIG2 is essential for beta 1 and beta 3 integrin activity due to its interactions with regulatory molecules such as talin and ILK. MIG2 contains two FERM domains (aa 285-326 and aa 524-573) and one pleckstrin homology domain (aa 373-478). Within the region used as an immunogen, human MIG2 shares 98% aa identity with mouse and rat MIG2. Two isoforms (687 aa and 633 aa) have a 7 aa insert after aa 534. The shorter isoform also has a 2 aa substitution for the C-terminal 57 aa of the 680 aa form.

Product Datasheets

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Adaptor Proteins
• Adhesion Molecules in Angiogenesis
• Focal Adhesions
• Integrins and Associated Molecules