Human/Mouse Adiponutrin/PNPLA3 Antibody

Mouse adiponutrin (also patatin-like phospholipase domain-containing protein 3) is a 45-48 kDa member of the adiponutrin family of phospholipase A2 enzymes. It is expressed in white and brown adipocytes, hepatocytes and brain. Adiponutrin is reduced in amount during fasting, and appears to act as an acute sensor of the body energy stores. Based on other family members, mouse adiponutrin is a type II transmembrane protein that is 413 amino acids (aa) in length. It contains one patatin domain (aa 10-179) that is associated with enzyme activity. There appear to be three splice variants. One shows a 69 aa substitution for aa 384-413, a second shows a deletion of aa 385-413, while a third shows a three aa substitution for aa 384-413. Over aa 160-327, mouse adiponutrin shares 84% and 62% aa identity with rat and human adiponutrin, respectively; and over aa 161-229, mouse adiponutrin shares 90% aa identity with human adiponutrin.