PLC-delta 3 (phospholipase C-delta 3) is an 105 kDa member of the delta -type PLC isozyme family. It is expressed in corneal epithelium, platelets, cardiac and skeletal muscle. PLC-delta 3 preferentially hydrolyzes membrane PIP2. This generates IP3, which induces intracellular Ca++ release, and DAG, activating PKC. Human PLC-delta 3 is 789 amino acids (aa) in length. It contains a plextrin homology domain that tethers the enzyme to the membrane (aa 63‑172), three EF-hand motifs that spatially orient the molecule (aa 182‑285), a catalytic region (aa 337‑644), and a C2 domain that secures the catalytic region to its substrate (aa 647‑752). There are multiple potential isoforms. There is an alternate start site at Met54, a 40 aa substitution for the C-terminal 248 aa, and a Leu substitution for aa 102‑109. Over aa 148‑344, human PLC-delta 3 is 93% aa identical to mouse PLC-delta 3.
Human/Mouse PLC-delta3 Alexa Fluor™ Plus 680‑conjugated Antibody
R&D Systems | Catalog # AF5315AFP680
Key Product Details
Species Reactivity
Applications
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Antibody Source
Product Specifications
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Host
Isotype
Applications for Human/Mouse PLC-delta3 Alexa Fluor™ Plus 680‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
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Stability & Storage
Background: PLC-delta 3
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UniProt
Additional PLC-delta 3 Products
Product Documents for Human/Mouse PLC-delta3 Alexa Fluor™ Plus 680‑conjugated Antibody
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Product Specific Notices for Human/Mouse PLC-delta3 Alexa Fluor™ Plus 680‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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- Cellular Response to Hypoxia Protocols
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
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- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
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