BOK (Bcl-2-related ovarian killer protein; also Bcl2L9 and Mtd) is a 27 kDa member of the Bax subgroup of the Bcl-2 family of molecules. It is expressed in spermatocytes, ovarian granulosa cells, and liver cells. BOK is activated by E2F proteins, and sensitizes replicating cells to apoptosis when under stress. It is normally found in the cytosol, and upon activation, becomes incorporated into mitochondrial membranes. Human BOK is 212 amino acids (aa) in length and contains one BH4 domain (aa 32‑44), one BH3 domain (aa 66‑82), a BH1 domain (aa 112‑131) and a BH2 domain (aa 164‑178). A potential transmembrane span has been identified between aa 189‑210. BOK heterodimerizes with Mcl-1, BHRF-1, Bfl-1 and Bnip3, and is known to form heterooligomers. There are two potential splice variants. One contains an alternative start site at Met145, while another shows a five aa substitution for aa 117‑212. Over aa 15‑123, human BOK shares 94% aa identity with mouse BOK.
Human/Mouse/Rat BOK Alexa Fluor™ Plus 405‑conjugated Antibody
R&D Systems | Catalog # AF6067AFP405
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human/Mouse/Rat BOK Alexa Fluor™ Plus 405‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
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Stability & Storage
Background: BOK
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UniProt
Additional BOK Products
Product Documents for Human/Mouse/Rat BOK Alexa Fluor™ Plus 405‑conjugated Antibody
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Product Specific Notices for Human/Mouse/Rat BOK Alexa Fluor™ Plus 405‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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