Protein phosphatase 2C alpha, also called PP2C alpha, Protein Phosphatase, Magnesium-dependent type 1A, and PPM1A, dephosphorylates proteins with some preference for phospho-threonine over phospho-serine residues (1). It is insensitive to the PP1 and PP2a inhibitors such as okadaic acid, (2) but has an absolute requirement for either magnesium or manganese ions (3) and can be activated by unsaturated fatty acids such as arachidonic and oleic acids (4). Overexpression of PP2C alpha causes G2/M cell cycle arrest and apoptosis that has been associated with the activation of p53 (5). Dephosphorylation of proteins in the nucleus by PP2C alpha is suspected to play a role in terminating or reducing the sensitivity of the responses to SMADS (6) and stress-activated proteins such as p38 and JNK (7).
Human/Mouse/Rat PP2C alpha /PPM1A Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # FAB4150AFP488
Key Product Details
Species Reactivity
Applications
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Antibody Source
Product Specifications
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Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: PP2C alpha/PPM1A
References
- Donella-Deanna, A. et al. (1991) Biochimica et Biophysica Acta 1094:130.
- Bialojan, C. and A. Takai (1998) Biochem. J. 256:283.
- Cohen, P. Annu. Rev. Biochem. (1989) 58:453.
- Klumpp, S. et al. (1998) FEBS Let. 437:229.
- Ofek, P. et al. (2003) J. Biol. Chem. 278:14299.
- Lin, X. et al. (2006) Cell 125:915.
- Takekawa, M. et al. (1998) EMBO J. 17:4744.
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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
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