Human/Mouse/Rat Talin1 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Talin1

Talin1 (talus; Latin for ankle, the shape of a focal adhesion plaque complex) is a 250‑270 kDa member of the I/LWEQ module superfamily. When activated, it serves as a cytoplasmic, homodimeric link between integrins and vinculin, an actin organizer. Human Talin1 is 2541 amino acids (aa) in length and contains one globular N‑terminal FERM domain that binds integrin cytodomains (aa 86‑403), and a rod shaped C‑terminus (aa 482‑2541) that binds vinculin, and contains an I/LWEQ dimerization domain (aa 2293‑2533). Over amino acids 975‑1181, human Talin1 shares 98% aa identity with mouse Talin1.

Product Datasheets

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on Endothelial Cells
• Adhesion Molecules on VSMC
• Extracellular Matrix Remodeling and Cell Migration During EMT
• Focal Adhesions
• Integrins and Associated Molecules
• Platelet Cytoskeleton and Granule Release
• Platelet Signaling
• T Cell Migration/Adhesion