Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate
Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate Summary
Preparation and Storage
TRIM63 (Tripartite motif-containing protein 63; also MURF-1, SMRZ and RING finger protein 28) is a 41 kDa member of the RING finger-B-box-coiled-coil family of proteins. It is a striated muscle protein that is found in both cytoplasm and nucleus. TRIM63 has multiple finctions, among which are the inhibition of PKC epsilon-mediated cardiomyocyte hypertrophy and the maintenance of skeletal muscle M-line integrity. Human TRIM63 is 353 amino acids (aa) in length. It contains one RING finger domain (aa 23-82), a B-Box type zinc-finger region (aa 117-159), a coiled-coil region (aa 207-269) and a C-terminal COS domain. Isoforms of TRIM63 show one potential alternate start site at Met14, a deletion of aa 105-132 and a 21 aa substitution for aa 326-353. Over aa 1-325, human TRIM63 exhibits 93% aa identity with mouse TRIM63.
Citation for Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.
Authors: van de Weijer M, Bassik M, Luteijn R, Voorburg C, Lohuis M, Kremmer E, Hoeben R, LeProust E, Chen S, Hoelen H, Ressing M, Patena W, Weissman J, McManus M, Wiertz E, Lebbink R
Nat Commun, 2014;5(0):3832. 2014
No product specific FAQs exist for this product, however you mayView all Activity Assay FAQs
Reviews for Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate
There are currently no reviews for this product. Be the first to review Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate and earn rewards!
Have you used Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image