Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate
Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate Summary
TRIM63 (Tripartite motif-containing protein 63; also MURF-1, SMRZ and RING finger protein 28) is a 41 kDa member of the RING finger-B-box-coiled-coil family of proteins. It is a striated muscle protein that is found in both cytoplasm and nucleus. TRIM63 has multiple finctions, among which are the inhibition of PKC epsilon-mediated cardiomyocyte hypertrophy and the maintenance of skeletal muscle M-line integrity. Human TRIM63 is 353 amino acids (aa) in length. It contains one RING finger domain (aa 23-82), a B-Box type zinc-finger region (aa 117-159), a coiled-coil region (aa 207-269) and a C-terminal COS domain. Isoforms of TRIM63 show one potential alternate start site at Met14, a deletion of aa 105-132 and a 21 aa substitution for aa 326-353. Over aa 1-325, human TRIM63 exhibits 93% aa identity with mouse TRIM63.
Citation for Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate
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1 Citation: Showing 1 - 1
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.
Authors: van de Weijer M, Bassik M, Luteijn R, Voorburg C, Lohuis M, Kremmer E, Hoeben R, LeProust E, Chen S, Hoelen H, Ressing M, Patena W, Weissman J, McManus M, Wiertz E, Lebbink R
Nat Commun, 2014;5(0):3832. 2014
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