Human Myocilin (NP_000252) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC2028
R&D Systems VersaClone cDNA Plasmids
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Human Myocilin (NP_000252) VersaClone cDNA Summary

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

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Background: Myocilin

Myocilin is a variably glycosylated, 65 kDa, secreted polypeptide that belongs to the family of olfactomedin-related proteins. Human Myocilin is synthesized as a 490 amino acid (aa) precursor that contains an 18 aa signal sequence, an 84 aa N-terminus containing a coiled-coil domain, a 53 aa alpha-helical leucine zipper and a 335 aa C-terminus that contains a 260 aa OLF-domain. An alternate start site generates a 504 aa mature protein without a signal sequence. Myocilin forms nondisulfide-linked dimers and multimers. The human 32 kDa OLF-domain shares 87% aa sequence identity with the OLF-domain in bovine, rat and mouse. Mutations in the OLF-domain of this protein can result in glaucoma.

Entrez Gene IDs
4653 (Human)
Alternate Names
GLC1A; GLC1Amyocilin; GPOA; JOAG; JOAG1; MYOC; Myocilin; myocilin, trabecular meshwork inducible glucocorticoid response; TIGR; TIGRmutated trabecular meshwork-induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein

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