Human NgR2/NgRH1 (NP_848665) VersaClone cDNA

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Human NgR2/NgRH1 (NP_848665) VersaClone cDNA
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Human NgR2/NgRH1 (NP_848665) VersaClone cDNA Summary


Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: NgR2/NgRH1

NgR2 (NgRH1, NgRL3) and NgR3 (NgRH2, NgRL2) have primary structures and biochemical properties that are homologous to Nogo-66 receptor (NgR), and constitute a novel neuronal receptor protein family. NgR is GPI-anchored and contains eight leucine-rich repeats (LRR); it is the neuronal receptor for the myelin- associated proteins Nogo-A, OMgp (oligodendrocyte myelin glycoprotein), and MAG (myelin-associated glycoprotein) and mediates the inhibition of CNS axonal regeneration both in vitro and in vivo. NgR2 and NgR3 have similar structure and distinct but overlapping expression versus NgR. NgR2 can be metalloproteinase-cleaved to release a soluble ectodomain. NgR2 has also been shown to bind MAG, but ligands for NgR3 have not yet been determined.

Long Name
Nogo-66 Receptor-related Protein 2/Nogo-66 Receptor Homolog 1/Reticulon-4 Receptor-like 2
Entrez Gene IDs
349667 (Human); 269295 (Mouse)
Alternate Names
NgR2; NgRH1; reticulon 4 receptor-like 2; RTN4RL2


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