Human NIK/MAP3K14 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6888RR Datasheet / COA / SDS

Recombinant Monoclonal Antibody

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FAB6888RR-100UG

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All NIK/MAP3K14 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NIK/MAP3K14 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human NIK/MAP3K14 in direct ELISAs.

Source

Monoclonal Mouse IgG2a Clone # 603917R

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human NIK/MAP3K14
Glu769-Pro947
Accession # Q99558

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NIK/MAP3K14

NIK (NF kappa B inducing kinase), also called MAP3K14, is a widely expressed 947 amino acid (aa), ~100 kDa cytoplasmic protein of the MAP kinase family. NIK participates in a non-canonical NFkB signaling cascade in which its activity and expression are elevated by TNF and related ligands. NIK activates IKKa/b, which releases NFkB subunits for translocation to the nucleus. Within the region used as an immunogen, human NIK shares 94% and 95% aa sequence identity with mouse and rat NIK, respectively.

Long Name

NF-kappa-beta Inducing Kinase

Entrez Gene IDs

9020 (Human); 53859 (Mouse); 360640 (Rat)

Alternate Names

EC 2.7.11.25; FTDCR1B; HS; HSNIK; HSNIKserine/threonine protein-kinase; MAP3K14; mitogen-activated protein kinase kinase kinase 14; NIK; NIKNF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK