Human NLRP2/NALP2 (NP_060322.1) VersaClone cDNA

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Human NLRP2/NALP2 (NP_060322.1) VersaClone cDNA
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Human NLRP2/NALP2 (NP_060322.1) VersaClone cDNA Summary


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Background: NLRP2/NALP2

NALP2 (NAcht Leucine-rich repeat Protein 2, also known as NLRP2 and PAN1) is a cytosolic, 121 kDa member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NF kappa B, it suppresses TNF-alpha production in response to LPS; via procaspase-1, it promotes proIL-1 beta cleavage and release. Human NALP2 is 1062 amino acids (aa) in length. It contains an N-terminal Pyrin domain (aa 9-90), followed by a Nacht region and nine LRRs (aa 467-1033). Four alternate isoforms exist. Three show deletions of aa's 109-132, 133-154 and 847-1062, respectively; a fourth shows a 38 aa substitution for aa's 1-903. No close rodent counterparts have been reported.

Long Name
NLR Family, Pyrin Domain Containing 2
Entrez Gene IDs
55655 (Human); 232827 (Mouse)
Alternate Names
CLR19.9; FLJ20510; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD domains-containing protein 2; NALP2; NALP2NACHT, LRR and PYD containing protein 2; NBS1; NBS1PYRIN-containing APAF1-like protein 2; NLR family, pyrin domain containing 2; NLRP2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2; PAN1; PAN1Nucleotide-binding site protein 1; PYPAF2; PYPAF2PYRIN domain and NACHT domain-containing protein 1


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