Natriuretic peptide receptor A/guanylate cyclase A (NPRA), also called NPR-1 or GC-A, is a 120 - 140 kDa type I transmembrane glycoprotein that is the primary receptor for natrietic peptides ANP and BNP. Binding of ANP to the extracellular ligand binding domain (aa 54 - 415), plus ATP to the intracellular kinase homology domain (aa 528 - 805) activates a cytoplasmic guanylate cyclase (aa 840 - 1023). NPRA is expressed most highly in kidney, adrenal and adipose tissue. Human NPRA extracellular domain shows 86%, 44% and 34% aa identity with mouse NPRA, human NPRB and human NPRC, respectively.
Human NPRA/NPR1 (NP_000897) VersaClone cDNA
R&D Systems | Catalog # RDC2877
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: NPRA/NPR1
Long Name
Natriuretic Peptide Receptor A
Alternate Names
ANPa, ANPRA, GC-A, GUCY2A, NPR1, NPRA, Pndr
Gene Symbol
NPR1
UniProt
Additional NPRA/NPR1 Products
Product Documents for Human NPRA/NPR1 (NP_000897) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human NPRA/NPR1 (NP_000897) VersaClone cDNA
For research use only
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