PKC delta (protein kinase C-delta) is a 78 kDa member of the PKC subfamily, AGC Ser/Thr protein kinase family of enzymes. It is a Ca++‑independent and phospholipid‑dependent ubiquitous enzyme that participates in cellular apoptosis. Human PKC delta is 676 amino acids (aa) in length. It contains two general regions: a phosphotyrosine and DAG-type 2 binding region (aa's 1‑90 and 159‑208, respectively), and an ATP-binding catalytic region (aa 349‑603). Functionally, inactive cytoplasmic PKC delta is first activated by Tyr64 and Tyr155 phosphorylation. This induces PKC delta entry into the nucleus, where it is cleaved into 43 kDa and 36 kDa fragments, initiating apoptosis. There are two potential alternate start sites for PKC delta at Met51 and Met74. In some cells, a poorly characterized 160 kDa form of PKC delta has been noted. Over aa 549‑676, human PKC delta is 85% aa identical to mouse PKC delta.
Human PKC delta Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # AF4585AFP488
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Applications for Human PKC delta Alexa Fluor™ Plus 488‑conjugated Antibody
Western Blot
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Background: PKC delta
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Product Specific Notices for Human PKC delta Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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- Cellular Response to Hypoxia Protocols
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- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
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