Human PSG Pan Specific Antibody
Human PSG Pan Specific Antibody Summary
Val36-Pro419
Accession # P11464
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human PSG by Western Blot. Western blot shows lysates of human placenta tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human PSG Pan Specific Monoclonal Antibody (Catalog # MAB6799) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Specific bands were detected for PSG at approximately 72 and 64 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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PSG in Human Placenta. PSG was detected in immersion fixed paraffin-embedded sections of human placenta using Mouse Anti-Human PSG Pan Specific Mono-clonal Antibody (Catalog # MAB6799) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytotrophoblast cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PSG
Pregnancy-specific beta-1-glycoprotein 1 (PSG-1), also called SP1, PSbG1 or B1G1 and designated CD66f, is a 54-72 kDa, 419 amino acid (aa) secreted glycoprotein of the human PSG family within the CEA (carcinoembryonic antigen) superfamily. PSG-1 shares limited aa sequence identity with mouse PSGs, but 84-91% aa sequence identity with human PSG-3, -4, -6, -7, and -8. Potential isoforms of 417-428 aa vary at the extreme C-terminus. PSG-1 is produced by syncytiotrophoblast cells and its concentration increases in maternal plasma as pregnancy progresses. Low plasma PSG-1 in the first or early second trimester has been correlated with fetal growth restriction. Expression of PSGs has also been detected in choriocarcinomas, hydatiform moles, ovarian adenocarcinomas, and breast tumors. During pregnancy, PSG-1 may play role in placental vascular morphogenesis and creation of an anti-inflammatory uterine environment.
Product Datasheets
Citation for Human PSG Pan Specific Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Pregnancy Specific ?-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival
J Cancer, 2016-10-17;7(14):2018-2027.
Species: Human, Mouse
Sample Types: Cell Lysates, Tissue Homogenates
Applications: Western Blot
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