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Human PTP beta / zeta /PTPRZ Antibody

Catalog #: MAB2688
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB2688
MAB2688-SP

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Detection of Human PTP beta / zeta /PTPRZ by Western Blot.
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Citations (3)
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Human PTP beta / zeta /PTPRZ Antibody Summary

Species Reactivity
Human
Specificity
Detects human PTP beta / zeta /PTPRZ in Western blots.
Source
Monoclonal Rat IgG1 Clone # 279244
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human PTP beta / zeta /PTPRZ
Gly302-Asn754
Accession # P23471
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human PTP beta /?/PTPRZ antibody by Western Blot. View Larger

Detection of Human PTP beta / zeta /PTPRZ by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 1 µg/mL of Rat Anti-Human PTP beta /zeta/PTPRZ Monoclonal Antibody (Catalog # MAB2688) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for PTP beta /zeta/PTPRZ at approximately 250 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PTP beta/zeta/PTPRZ

Protein tyrosine phosphatase beta/zeta (PTP beta / zeta ), also known as PTPRZ, is a member of the receptor-type protein-tyrosine phosphatase family. This phosphatase is involved in the regulation of specific developmental processes in the central nervous system. A protein of 2,307 amino acids, PTPRZ is membrane-spanning with two cytoplasmic protein tyrosine phosphatase domains and an extracellular domain.

Long Name
Protein Tyrosine Phosphatase beta/zeta
Entrez Gene IDs
5803 (Human)
Alternate Names
3F8 CSPG ; HPTPZ; phosphacan; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; PTP beta/zeta; PTP18; PTPRZ; PTPRZ1; PTPZ; receptor-type, zeta polypeptide 1; RPTPB; RPTPbeta

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Citations for Human PTP beta / zeta /PTPRZ Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway
    Authors: Rania Elahouel, Charly Blanc, Gilles Carpentier, Sophie Frechault, Ilaria Cascone, Damien Destouches et al.
    Neoplasia
  2. Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target.
    Authors: Jin Z, Lahat G, Korchin B, Nguyen T, Zhu QS, Wang X, Lazar AJ, Trent J, Pollock RE, Lev D
    Clin. Cancer Res., 2008-08-15;14(16):5033-42.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Pleiotrophin prevents cocaine-induced toxicity in vitro.
    Authors: Gramage E, Alguacil LF, Herradon G
    Eur. J. Pharmacol., 2008-08-13;595(1):35-8.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot

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