Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA

Name: Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA
Brand: R&D Systems
SKU: RDC2900
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC2900

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_001351952

Background: ROR beta/NR1F2

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain. ESTs have been isolated from human tissue libraries, including cancerous human kidney and normal brain, pineal and eye.

Long Name

Retinoic Acid-Related Orphan Receptor beta

Alternate Names

NR1F2, RORB, RZRB

Entrez Gene IDs

6096 (Human)

Gene Symbol

RORB

UniProt

NP_001351952

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Product Specific Notices for Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA

For research use only

Related Research Areas

Nuclear Hormone Receptors and Regulators

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