Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA

R&D Systems | Catalog # RDC2900

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Key Product Details

Species

Human

Accession Number

NP_001351952

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ROR beta/NR1F2

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain. ESTs have been isolated from human tissue libraries, including cancerous human kidney and normal brain, pineal and eye.

Long Name

Retinoic Acid-Related Orphan Receptor beta

Alternate Names

NR1F2, RORB, RZRB

Entrez Gene IDs

6096 (Human)

Gene Symbol

RORB

UniProt

NP_001351952

Additional ROR beta/NR1F2 Products

Product Documents for Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human ROR beta/NR1F2 (NP_001351952) VersaClone cDNA

For research use only

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