Human Serpin A5/Protein C Inhibitor Alexa Fluor® 750-conjugated Antibody

Catalog #: AF1266S Datasheet / COA / SDS

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AF1266S-100UG

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All Serpin A5/Protein C Inhibitor Antibodies

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Human Serpin A5/Protein C Inhibitor Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Serpin A5/Protein C in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Serpin A1, rhSerpin A3, rhSerpin A4, rhSerpin A9, and rhSerpin A11 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin A5/Protein C Inhibitor
His20-Pro406
Accession # P05154

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Serpin A5/Protein C Inhibitor

Serpin A5 is the a member of the Serpin superfamily and inhibits a variety of serine proteases such as protein C, plasminogen activators, thrombin, factor Xa, several kallekreins and acrosin (1). Serpin A5 is synthesized in the liver and secreted in plasma. It is found in numerous steroid-responsive organs and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. Because of its protease targets and regulated expression patterns, Serpin A5 has been proposed to play a role in processes such as blood coagulation, fertilization and carcinogenesis (2, 3). Similar to Serpins C1 and D1, its thrombin inhibitory activity is enhanced by heparin.

Entrez Gene IDs

5104 (Human); 268591 (Mouse)

Alternate Names

Acrosomal serine protease inhibitor; antitrypsin), member 5; member 5; PAI-3; PAI3PLANH3; PCI; PCIplasminogen activator inhibitor III; Plasminogen activator inhibitor 3; plasminogen activator inhibitor-3; PROCIplasma serine protease inhibitor; Protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; Serpin A5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin); SERPNA5