Human ST6 Gal Sialyltransferase 1/
ST6GAL1 Alexa Fluor™ Plus 680‑conjugated Antibody

R&D Systems | Catalog # FAB5924AFP680

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 396012
View all ST6 Gal Sialyltransferase 1/ST6GAL1 Primary Antibodies »

Product Specifications

Specificity

Detects human ST6 Gal Sialytransferase 1/ST6GAL1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) ST6GAL2, rhST6GALNAC1, or rhST6GALNAC5 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ST6 Gal Sialyltransferase 1/ST6GAL1

ST6GAL1 ( beta -galactoside alpha -2-6 sialyl transferase 1; also alpha -2,6-ST) is a 47-49 kDa member of the glycosyltransferase 29 family of proteins. It is principally expressed in hepatocytes, placenta and skeletal muscle, and may be unique in its ability to generate Sia-alpha -2, 6-Gal structures on liver proteins. Human ST6GAL1 is a 406 amino acid (aa) type II transmembrane protein that resides in Golgi membranes. It contains a short cytoplasmic segment (aa 1-9) and an extended luminal domain
(aa 27‑406) that possesses a phosphorylation site at Tyr369. ST6GAL1 undergoes BACE1-mediated cleavage to generate a 364 aa, 52-53 kDa soluble form. This acts within the Golgi lumen to glycosylate proteins destined for secretion. There is one potential alternative start site at Met232. Over aa 27‑406, human ST6GAL1 shares 75% aa identity with mouse ST6GAL1.

Long Name

ST6 beta-Galactoside alpha-2,6-Sialyltransferase 1

Alternate Names

Alpha 2,6-ST, B-cell antigen CD75, CD75, SIAT1, ST6N

Entrez Gene IDs

6480 (Human); 20440 (Mouse); 25197 (Rat)

Gene Symbol

ST6GAL1

UniProt

P15907

Additional ST6 Gal Sialyltransferase 1/ST6GAL1 Products

Product Documents

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Glycobiology-related Enzymes

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