Human TAP2 (NP_000535) VersaClone cDNA

R&D Systems | Catalog # RDC2432

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Key Product Details

Species

Human

Accession Number

NP_000535

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: TAP2

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq]

Long Name

Transporter 2, ATP Binding Cassette Subfamily B Member

Alternate Names

ABC18, ABCB3, APT2, PSF2, RING11

Entrez Gene IDs

6891 (Human); 21355 (Mouse); 24812 (Rat)

Gene Symbol

TAP2

UniProt

NP_000535

Additional TAP2 Products

Product Documents for Human TAP2 (NP_000535) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human TAP2 (NP_000535) VersaClone cDNA

For research use only

Related Research Areas

Cancer Biomarkers
Diabetes

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