Testican 2 encoded by the SPOCK2 gene is a proteoglycan highly expressed in brain (1, 2). The human and mouse cDNAs predict 94% identity between the deduced amino acid sequences from the two species, indicating a conserved function (3, 4). Testican 2 contains a Ca2+-binding domain and a C-terminal acidic domain with putative glycosaminoglycan attachment sites. In addition, it contains three potential inhibitory domains targeted toward three different classes of proteases, metallo, cysteine and serine proteases. However, these domains may not be involved directly in the inhibition of targeted proteases. For example, Testican 2 is not able to inhibit MMP-14 (MT1-MMP, a metalloprotease) activation of MMP-2 (5). Nonetheless, overexpression of Testican 2 is able to abrogate inhibition of MMP-14 by other testican family members and to inhibit neurite outgrowth (6, 7).
Human Testican 2/SPOCK2 Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # FAB2328AFP488
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human Testican 2/SPOCK2 Alexa Fluor™ Plus 488‑conjugated Antibody
Immunoprecipitation
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: Testican 2/SPOCK2
References
- Nagase, T. et al. (1996) DNA Res. 3:321.
- Vannahme, C. et al. (1999) J. Neurochem. 73:12.
- Strausberg, R.L. et al. (2002) Proc. Natl. Acad. Sci. USA 99:16899.
- Okazaki, Y. et al. (2002) Nature 420:563.
- Nakada, M. et al. (2001) Cancer Res. 61:8896.
- Nakada, M. et al. (2003) Cancer Res. 63:3364.
- Hartmann, U. and P. Maurer (2001) Matrix Biol. 20:23.
Alternate Names
Entrez Gene IDs
Gene Symbol
UniProt
Additional Testican 2/SPOCK2 Products
Product Documents for Human Testican 2/SPOCK2 Alexa Fluor™ Plus 488‑conjugated Antibody
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Product Specific Notices for Human Testican 2/SPOCK2 Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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Protocols
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- Cellular Response to Hypoxia Protocols
- Immunoprecipitation Protocol
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars