Human Thyroglobulin Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB8306N Datasheet / COA / SDS

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FAB8306N-100UG

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Human Thyroglobulin Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Thyroglobulin in direct ELISAs.

Source

Monoclonal Mouse IgG1 Clone # 904802

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Thyroglobulin
Met1-Lys2768
Accession # P01266

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Thyroglobulin

Human Thyroglobulin (Tg) gene is localized at position 8q242-8q243. The gene covers a genome area of at least 300 000 bp and contains at least 37 exons. Thyroglobulin (Tg) is a dimeric 660 kDa glycoprotein produced by follicular cells (thyrocytes) in thyroid gland and stored in the follicular colloid of the gland. Tg is heterogenic due to post-translational modifications, such as iodination, glycosylation, sulfatation, phosphorylation and it is highly sensitivity to proteolysis. Acting as a substrate, Tg is used for the synthesis of thyroid hormones thyroxine (T4) and triiodothyronine (T3). Tg level can serve as a tumor marker of papillary and follicular thyroid cancer and elevated levels of anti-Tg antibodies in blood can be indicative of Graves disease.

Entrez Gene IDs

7038 (Human); 21819 (Mouse); 24826 (Rat)

Alternate Names

AITD3; AITD3TGN; cog; TDH3; Tg; TGN; Thyroglobulin