Detection of TM4SF4 in HT‑29 Human Cell Line by Flow Cytometry. HT‑29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human TM4SF4 PE‑conjugated Monoclonal Antibody (Catalog # FAB7998P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
TM4SF4 (Transmembrane 4 L6 Family Member 4), also known as IL-TMP (Intestine and Liver Tetraspanin Membrane Protein), is a distant member of the tetraspanin L6 domain family of molecules. It is expressed at highest levels on non-proliferating villus-associated intestinal epithelia of the jejunum, periportal hepatocytes, and follicle-associated epithelium of the ileum. It is thought to mediate proliferation and adhesion, and is now known to complex with THTR-2 (Thiamine Transporter-2) during the transport of thiamine into expressing cells. Its molecular size is reported at approximately 21 kDa for the unglycosylated form and varies from 25-30 kDa on proliferating cells, to 25-40 kDa on non-proliferating cells. The 202 amino acid (aa) human TM4SF4 contains four transmembrane domains and two potential N-glycosylation sites. The extracellular region of human TM4SF4 shares 72% aa sequence identity with mouse TM4SF4.
Transmembrane 4 L Six Family Member 4
Entrez Gene IDs:
7104 (Human); 229302 (Mouse); 116467 (Rat)
FLJ31015; ILTMP; il-TMP; ILTMPintestinal and liver (il) tetraspan membrane protein; Intestine and liver tetraspan membrane protein; transmembrane 4 L six family member 4; transmembrane 4 L6 family member 4; transmembrane 4 superfamily member 4
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