Human TMPRSS3 (NP_076927.1) VersaClone cDNA

R&D Systems | Catalog # RDC3340

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Key Product Details

Species

Human

Accession Number

NP_076927.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: TMPRSS3

Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochlea, a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.

Long Name

TransmembraneSerine Protease 3

Alternate Names

DFNB10, DFNB8, ECHOS1, TADG12

Entrez Gene IDs

64699 (Human)

Gene Symbol

TMPRSS3

UniProt

NP_076927.1 (Human)

Additional TMPRSS3 Products

Product Documents for Human TMPRSS3 (NP_076927.1) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human TMPRSS3 (NP_076927.1) VersaClone cDNA

For research use only

Related Research Areas

Serine Proteases and Regulators

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